Sunday, September 30, 2012

MUSIGA To Vomit ?20 Billion

The Musicians Union of Ghana (MUSIGA) has been asked to account for the GH?2 million (?20 billion) the Government of Ghana set aside in the 2012 budget to boost the creative arts industry.MUSIGA has gone for the money and is using it without the approval of other stakeholders in the creative arts industry and this has led to some bad blood between the union and other stakeholders in the creative arts industry.

The Music Council of Ghana (MCG) will be leading a delegation of music/creative arts stakeholders to present a petition to President John Mahama over the issue and also hit the streets on a demonstration meant to draw attention to the issue of the GH?2 million.

Reports reaching NEWS-ONE say MUSIGA is hot over the issue and has fallen on leading figures within the industry to call for a dialogue rather than demonstration.

On Wednesday, Ahuma Ocansey, popularly known as Daddy Bosco, was said to have represented MUSIGA at a meeting with the aggrieved stakeholders and pleaded for an amicable settlement of the matter.

Meanwhile, MUSIGA President Bice Obour Kufour is cooling off in New York, apparently absolutely unperturbed about the development.

A press statement signed by Justice Cletus ,general secretary, Music Council of Ghana noted: ?After waiting patiently for the Government through the Ministry of Chieftaincy & Culture to invite all stakeholders in the music/creative industry for appropriate disbursement of the GH?2, 000,000 budgetary allocation from the government of Ghana to the entire creative industry, we are indeed heartbroken and refuse to accept any such criteria or justification which warranted the total disbursement of this whole sum to one union of musicians called MUSIGA by the Ministry of Finance in collaboration with the Chieftaincy Ministry.

?MUSIGA does not represent the interest of the entirety of the Ghanaian Music/Creative industry and we don?t see any error or oversight that some may want to use to cover the role played by both the Ministries of Finance & Chieftaincy/Culture towards the processing and facilitation of this very questionable disbursement which His Excellency, the President of the Republic of Ghana has openly condemned and disassociated himself from the dubious payment of the said amount to MUSIGA.?

Not long after the budget was read, MUSIGA President Bice ?Obour? Kufour told several media houses that the money was for his musicians union alone and true to his words, they have hijacked the funds and left out all other stakeholders.

Speaking with Hitz FM, an Accra-based private radio station recently, ace hi-life musician Rex Omar, who is chairman of Business for MUSIGA, insisted that the money solely belonged to the musicians union, contrary to speculations.

According to him, ?MUSIGA applied for GH?2 million and it has been given to MUSIGA,? adding, if the money was meant for the creative industry, ?how come MUSIGA was able to access it and not the creative industry?

MUSIGA sent a specific proposal to do specific things?.

Meanwhile, the circumstances under which the Ministry of Finance released the money to MUSIGA alone are quite mysterious, especially when the Minister of Finance, in reading the budget statement, had categorically stated that the money was for the creative arts industry.

The Finance Minister, when he made the announcement, even went on to explain what he meant by the creative arts industry:

?Madam Speaker, Ghana has a vibrant creative arts industry that can be nurtured to create jobs and provide increase income to all stakeholders.

The industry covers creative sectors such as music, film video and photography, visual and performing arts, publishing, etc.

Global trade in creative goods and services remained very robust during the financial and economic meltdown, with the value of global export of creative goods and services reaching nearly US$600 billion between 2002 and 2008.?

?193. Ghana can benefit immensely if it begins to tap the creative sector of the economy, particularly those of the music and film industry.

But this will require an evaluation of the potential of the creative industry to contribute to the growth of the economy.

Beginning in 2012, therefore, Government will collaborate with the music industry to identify the potential of the industry through an impact assessment study.

The study will be used to support the preparation of a medium term strategic framework that will guide the development of the industry.

Government will also support the organisation of the 2012 Ghana Music Fair.

?194. An amount of GH?2.0 million has been allocated to support the creative arts industry in 2012,?was what Finance Minister Dufour told Parliament when he read the 2012 budget last year November.

This is what is also captured in the 2012 budget under the subhead line ?Boosting the Creative Arts Industry?.

Source: http://www.ghanashowbiz.com/news/musiga-to-vomit-%C2%A220-billion/

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Ex-NY Times publisher Arthur Ochs Sulzberger dies

FILE - This March 2m, 1973 file photo shows New York Times publisher Arthur Ochs Sulzberger in his office in New York. Sulzberger has died at age 86. The newspaper reports that his family says Sulzberger died Saturday, Sept. 29, 2012, at his home in Southampton, N.Y., after a long illness. He had retired in 1992 after three decades at the paper's helm and was succeeded by his son, Arthur Jr. (AP Photo/Anthony Camerano, File

FILE - This March 2m, 1973 file photo shows New York Times publisher Arthur Ochs Sulzberger in his office in New York. Sulzberger has died at age 86. The newspaper reports that his family says Sulzberger died Saturday, Sept. 29, 2012, at his home in Southampton, N.Y., after a long illness. He had retired in 1992 after three decades at the paper's helm and was succeeded by his son, Arthur Jr. (AP Photo/Anthony Camerano, File

FILE - This March 12, 1973 file photo shows New York Times publisher Arthur Ochs Sulzberger in his office in New York. Sulzberger has died at age 86. The newspaper reports that his family says Sulzberger died Saturday, Sept. 29, 2012, at his home in Southampton, N.Y., after a long illness. He had retired in 1992 after three decades at the paper's helm and was succeeded by his son, Arthur Jr. (AP Photo/Anthony Camerano, File)

FILE - In this May 26, 1992 file photo, Paris Mayor Jacques Chirac, flanked by Washington Post Company President Katharine Graham, left, and New York Times Company President Arthur Ochs Sulzberger, after awarding them the Paris City Medal, in Paris. Sulzberger has died at age 86. The newspaper reports that his family says Sulzberger died Saturday, Sept. 29, 2012, at his home in Southampton, N.Y., after a long illness. He had retired in 1992 after three decades at the paper's helm and was succeeded by his son, Arthur Jr. (AP Photo/Jose Goita)

FILE - This July 20, 1977 file photo shows New York Times publisher Arthur Ochs Sulzberger in his office in New York. Sulzberger has died at age 86. The newspaper reports that his family says Sulzberger died Saturday, Sept. 29, 2012, at his home in Southampton, N.Y., after a long illness. He had retired in 1992 after three decades at the paper's helm and was succeeded by his son, Arthur Jr. (AP Photo/Ray Howard, File)

FILE - This March 2, 1973 file photo shows New York Times publisher Arthur Ochs Sulzberger in his office in New York. Sulzberger has died at age 86. The newspaper reports that his family says Sulzberger died Saturday, Sept. 29, 2012, at his home in Southampton, N.Y., after a long illness. He had retired in 1992 after three decades at the paper's helm and was succeeded by his son, Arthur Jr. (AP Photo/Anthony Camerano, File)

NEW YORK (AP) ? Former New York Times publisher Arthur Ochs Sulzberger, who led the newspaper to new levels of influence and profit while standing up for press freedom and editorial independence during some of the most significant moments in 20th-century journalism, died Saturday. He was 86.

Sulzberger, who went by the nickname "Punch" and served with the Marine Corps before joining the Times staff as a reporter, and then following his father and grandfather as publisher, died at his home in Southampton, N.Y., after a long illness, his family announced.

During his three-decade-long tenure, the newspaper won 31 Pulitzer prizes, published the Pentagon Papers and won a libel case victory in New York Times vs. Sullivan that established important First Amendment protections for the press.

"Punch, the old Marine captain who never backed down from a fight, was an absolutely fierce defender of the freedom of the press," his son, and current Times publisher, Arthur Ochs Sulzberger Jr., said in a statement. He said his father's refusal to back down in the paper's free-speech battles "helped to expand access to critical information and to prevent government censorship and intimidation."

In an era of declining newspaper readership, the Times' weekday circulation climbed from 714,000 when Sulzberger became publisher in 1963 to 1.1 million upon his retirement as publisher in 1992. Over the same period, the annual revenues of the Times' corporate parent rose from $100 million to $1.7 billion.

"Above all, he took the quality of the product up to an entirely new level," the late Katharine Graham, chairwoman of The Washington Post Co., said at the time Sulzberger relinquished the publisher's title. When she died in 2001, he returned the praise, saying she "used her intelligence, her courage and her wit to transform the landscape of American journalism."

Sulzberger was the only grandson of Adolph S. Ochs (pronounced ox), the son of Bavarian immigrants who took over the Times in 1896 and built it into the nation's most influential newspaper. The family retains a controlling interest to this day, holding a separate block of Class B shares that have more powerful voting rights than the company's publicly traded shares.

Power was thrust on Sulzberger at the age of 37 after the sudden death of his brother-in-law in 1963. He had been in the Times executive suite for eight years in a role he later described as "vice president in charge of nothing."

But Sulzberger directed the Times' evolution from an encyclopedic paper of record to a more reader-friendly product that reached into the suburbs and across the nation.

During his tenure, the Times started a national edition, bought its first color presses, and introduced popular as well as lucrative new sections covering topics such as science, food and entertainment.

A key figure in the transformation was A.M. Rosenthal, executive editor from 1977 to 1986. Rosenthal, who died in 2006, called Sulzberger "probably the best publisher in modern American history."

Sulzberger also improved the paper's bottom line, pulling it and its parent company out of a tailspin in the mid-1970s and lifting both to unprecedented profitability a decade later.

In 1992, Sulzberger relinquished the publisher's job to his 40-year-old son, Arthur Ochs Sulzberger Jr., but remained chairman of The New York Times Co.

Sulzberger retired as chairman and chief executive of the company in 1997. His son then was named chairman. Sulzberger stayed on the Times Co. board of directors until 2002.

Significant free-press and free-speech precedents were established during Sulzberger's years as publisher, most notably the Times vs. Sullivan case. It resulted in a landmark 1964 Supreme Court ruling that shielded the press from libel lawsuits by public officials unless they could prove actual malice.

In 1971 the Times led the First Amendment fight to keep the government from suppressing the Pentagon Papers, a series of classified reports on the Vietnam War. Asked by a reporter who at the Times made the decision to publish the papers, Sulzberger gestured toward his chest and silently mouthed, "me."

Sulzberger read the more than 7,000 pages of the Pentagon Papers before deciding to publish them. After Sulzberger read the papers, he was asked what he thought. "Oh, I would think about 20 years to life," he responded.

But in a landmark decision, the U.S. Supreme Court eventually sided with the Times and The Washington Post, which had begun publishing the papers a few days after the Times.

"Punch Sulzberger was a giant in the industry, a leader who fought to preserve the vital role of a free press in society and championed journalism executed at the highest level," said Associated Press President and CEO Gary Pruitt. "The Associated Press benefited from his wisdom, both during his years on the board of directors and his thoughtful engagement in the years that followed."

Gay Talese, who worked at the Times as a reporter when Sulzberger took over and chronicled the paper's history in his book "The Kingdom and the Power," called him "a brilliant publisher. He far exceeded the achievements of his father in both making the paper better and more profitable at a time when papers are not as good as they used to be."

In their book "The Trust," a history of the Ochs-Sulzberger family and its stewardship of the paper, Susan E. Tifft and Alex S. Jones cited Sulzberger's "common sense and unerring instincts."

In an interview in 1990 with New York magazine, Sulzberger was typically candid about the paper's readership.

"We're not New York's hometown newspaper," he said. "We're read on Park Avenue, but we don't do well in Chinatown or the east Bronx. We have to approach journalism differently than, say, the Sarasota Herald Tribune, where you try to blanket the community."

New York City's mayor from 1978 to 1989, Ed Koch, said Sulzberger also had great humility, despite his extraordinary influence.

"With enormous power and authority he was a humble a person as you could ever meet," Koch said Saturday. "People with enormous power often dominate a room. He did not. And yet the power and authority was there."

In the mid-1980s Sulzberger authorized the building of a $450 million color printing and distribution plant across the Hudson River in Edison, N.J., part of a plan to get all printing out of cramped facilities in the Times building in Manhattan.

Sulzberger was born in New York City on Feb. 5, 1926, the only son of Arthur Hays Sulzberger and his wife, Iphigene Ochs Sulzberger, Adolph's only child. One of his three sisters was named Judy, and from early on he was known as "Punch," from the puppet characters Punch and Judy.

Sulzberger's grandfather led the paper until his death in 1935, when he was followed by Sulzberger's father, who remained at the helm until he retired in 1961.

Meanwhile, Arthur served in the Marines during World War II and, briefly, in Korea. He later observed, in a typically self-deprecating remark, that "My family didn't worry about me for a minute. They knew that if I got shot in the head it wouldn't do any harm."

Except for a year at The Milwaukee Journal, 1953-54, the younger Sulzberger spent his entire career at the family paper. He joined after graduating from Columbia College in 1951. He worked in European bureaus for a time and was back in New York by 1955, but found he had little to do.

Sulzberger had not been expected to assume power at the paper for years. His father passed control to Orvil E. Dryfoos, his oldest daughter's husband, in 1961. But two years later Dryfoos died suddenly of heart disease at 50. Punch Sulzberger's parents named him publisher, the fourth family member to hold the title.

"We had all hoped that Punch would have many years more training before having to take over," said his mother, Iphigene. Sulzberger relied on senior editors and managers for advice, and quickly developed a reputation as a solid leader.

At various times, Sulzberger was a director or chairman of the Newspaper Advertising Bureau, American Newspaper Publishers Association and American Press Institute. He was a director of The Associated Press from 1975 to 1984.

Sulzberger married Barbara Grant in 1948, and the couple had two children, Arthur Jr. and Karen. After a divorce in 1956, Sulzberger married Carol Fox. The couple had a daughter, Cynthia, and Sulzberger adopted Fox's daughter from a previous marriage, Cathy.

Carol Sulzberger died in 1995. The following year, Sulzberger married Allison Cowles, the widow of William H. Cowles 3rd, who was the president and publisher of The Spokesman-Review and Spokane Chronicle of Spokane, Wash.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-09-29-Obit-Sulzberger/id-5119d87692af4eadbea206129ee08700

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Tales of the Immortalis

Tales of the Immortalis

Help God and His Immortali to repel the Devil and his Immortali, and protect humanity in the Medeival Europe where a tyrant rules with an iron fist. Beware, as the beings you vow to protect will lash out against you in fear.

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I have a thousand years of experience, went through a thousand years of battles, and have a thousand years of wisdom. What makes you think you'd out-smart me?
If you've known the true number of years I lived, you'd see why I'm excellent in world history.

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Saturday, September 29, 2012

Video: Momtrepreneurs turn kids? ideas into companies



>>> if you're parents chances are you've thought of a couple of inventions that would make your life a lot easier. soleil moon frye and author of "happy chaos" found several families who put their ideas to work. good morning again, soleil.

>> good morning. you're sort of a momtreprenuer yourself.

>> never a better time to be a momtreprenuer.

>> when my partner and i started little feeds searched the globe for products at your home, your garage. because of social media , never been a better time, start a twitter account, facebook account and start something from your own home which is so incredibly insparing and some of these products were fund from home.

>> great companies started off with the first one.

>> original sprout, such a fun company. started by a mom named inga, a daughter named maya, wanted healthy products for her little one. i love that the sunblock is so natural. i use this on my girls.

>> no parabins. free and clear of everything.

>> exactly.

>> super curly hair so the miracle detangler is incredible. it's a family business . they live on a farm. they create it in their home. i love that it's, you know, a family-run business.

>> yeah.

>> again, if you have that thought in your head and you think of something amazing and know that the world is going to connect to it, if you're thinking about it, i bet a lot of other people will also connect.

>> by the way this, body lotion smells amazing, my favorite. love it.

>> over here. this is a company, i but this stuff for my kids when they were smaller. called happy family .

>> happy family . tell me the family about this.

>> it was started by shazy who wanted to create an organic baby food company and we all love the pouches.

>> so easy to cary.

>> so much easier for our little ones , and it was launched on mother's day, and she's a mom, and she is a true momtrepreneur. so many options, organic baby food at your fingertips.

>> great little puffs my kids love.

>> yes.

>> over here, little wood alouette is the maker of this toy company, make these cute little wood toys and a mom and dad started this company because they wanted to create dies for their boys.

>> one of my favorite, little alouette. the dad was a carpenter and the mom and dad started this company. they had three children. they are so amazing. they make this from their heart and soul, all eco-friendly and beautifully designed. she's a poet. one of those amazing stories , and it connects to people.

>> they look great. cleanwell, also something that we know and love. those of us with little kids and spraying the anti-bacterial on them and use the hand wipes. tell me about this.

>> absolutely. this was started by a dad who is son had an immune disorder, and literally he was so concerned about his son he wanted to create disinfect ants and a healthy option for his child. you have all these incredible cleaning products and all these amazing disinfectants, hand wipes, i mean, it's amazing. i love this one, use it all the time and have it in my purse at all times.

>> they are great.

>> tons of great products here.

>> finally, last but not least, the juicery.

>> one of our favorites.

>> introduced to this when i was out in california and just love the flavors. now tell me how they started this.

>> it is so delicious. two of the co-founders are moms, of course, and they are just amazing. they wanted healthy options. one of the momt moms, you know, her mother had died from cancer. they wanted to look into healthy options. go online and order t.started it with one store and now they have five stores. they are going into eight stores, and i just love it's such a true story of entrepreneurship, and you've got to try it.

>> i love the vanilla almond one so i'm going for that one. soleil moon frye

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Kristen Bell hits Target in product-placement film

FILE - This Jan. 6, 2012 file photo shows actress Kristen Bell in New York. Target is releasing an episodic series of short films starring Kristen Bell and Nia Long and everything on screen is for sale. The company unveiled the three episodes of "Falling for You" Thursday, Sept. 27, at a private event at the SLS Hotel in Los Angeles. (AP Photo/Carlo Allegri, file)

FILE - This Jan. 6, 2012 file photo shows actress Kristen Bell in New York. Target is releasing an episodic series of short films starring Kristen Bell and Nia Long and everything on screen is for sale. The company unveiled the three episodes of "Falling for You" Thursday, Sept. 27, at a private event at the SLS Hotel in Los Angeles. (AP Photo/Carlo Allegri, file)

(AP) ? Talk about product placement: Target is releasing an episodic series of short films starring Kristen Bell and Nia Long and everything on-screen is for sale.

The company unveiled the three episodes of "Falling for You" on Thursday at a private event at the SLS Hotel in Los Angeles.

Bell plays an advertising exec and Long is her boss in "Falling for You." Zachary Abel plays Bell's rival ? and potential love interest ? in the series, wherein online viewers can click on any item on-screen and add it to their shopping carts, from fashion to housewares.

"It's a very exciting concept," Bell said. "It felt very fluid. A lot of it is just showing things in their natural habitat. I felt like it was more natural than a product-placement situation (on a film set)."

More than 100 products are featured in the three-episode arc. "Falling for You" will begin airing Oct. 2 and the products featured will be available until Nov. 1.

___

AP Entertainment Writer Sandy Cohen is on Twitter: www.twitter.com/APSandy .

___

Online:

http://fallingforyou.target.com/

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-09-28-Film-Target/id-8d1b9a8462494437afd2a99541ee0caa

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Friday, September 28, 2012

Breakthrough on immune system and brain tumors

ScienceDaily (Sep. 26, 2012) ? In what could be a breakthrough in the treatment of deadly brain tumors, a team of researchers from Barrow Neurological Institute and Arizona State University has discovered that the immune system reacts differently to different types of brain tissue, shedding light on why cancerous brain tumors are so difficult to treat.

The large, two-part study, led by Barrow research fellow Sergiy Kushchayev, MD under the guidance of Dr. Mark Preul, Director of Neurosurgery Research, was published in the Sept. 14 issue of Cancer Management and Research. The study explores the effects of immunotherapy on malignant gliomas, cancerous brain tumors that typically have a poor prognosis.

What the researchers discovered was that immune cells of the brain and of the blood exhibit massive rearrangements when interacting with a malignant glioma under treatment. Essentially, the study demonstrates that the complex immune system reacts differently in different brain tissues and different regions of the brain, including tumors.

"This is the first time that researchers have conducted a regional tissue study of the brain and a malignant glioma to show that these immune cells do not aggregate or behave in the same way in their respective areas of the brain," says Dr. Preul. "This means that effective treatment in one area of the brain may not be effective in another area. In fact, it could even cause other regions of the tumor to become worse."

The results of the study provide important insight into why clinical trials involving immunotherapies on glioma patients may not be working.

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The above story is reprinted from materials provided by St. Joseph's Hospital and Medical Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Mark Preul, Laura L. Eggink, Yevgeniya S. Kushchayeva, Philip C. Wiener, J. Kenneth Hoober, Jennifer Eschbacher, Fu-Dong Shi, Ruolan Liu, Mohammed Abdelwahab, Adrienne C. Scheck, Sergiy Kushchayev, Sankar. Monocyte galactose/N-acetylgalactosamine-specific C-type lectin receptor stimulant immunotherapy of an experimental glioma. Part 1: stimulatory effects on blood monocytes and monocyte-derived cells of the brain. Cancer Management and Research, 2012; : 309 DOI: 10.2147/CMAR.S33248

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/T1kki0G5BMg/120927092128.htm

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Adwords has Become an Accessible and Valuable Tool for Early ...

We have had direct experience with Google Adwords as a premium online advertising option over several years. Originally we undertook some management of a campaign established by a client in a retail business for formal apparel. Most recently we are managing campaigns for clients in enterprise IT technology businesses. We can finally say, with confidence, that Google Adwords is now a method of product promotion that meets our standards for accessibility and likelihood of return on investment (ROI).

The biggest difference between then and now is the availability, for 6 weeks at the start of any Google Adwords campaign, of unlimited technical assistance for any Adwords advertiser. This new feature goes a very long way to help technically knowledgeable organizations like ours to make better use of Adwords features, particularly as they can be coordinated with Google Analytics. For example, we can now get very granular as to how we manage keywords, literally turning them on or off, as required, on a daily basis as we fine tune client campaigns.

This granular control is a very big plus as our clients, across the board, have let us know that a big issue with Adwords has been the comparative high cost of utilizing this method. A familiar phrase that we used to hear from clients about Adwords was ?out of control.? Somehow campaigns got out of control. Costs escalated and, in keeping with this escalation, true return on investment contracted. In contrast, today we can say with confidence that we can truly turn off what is NOT working very promptly to keep client costs within a workable range. Of most importance, for a likely few hundred dollars in click or CPM costs, at the onset of a campaign, our clients can develop a useful set of keywords that will deliver the sales required to maintain campaigns and grow overall business.

We would like to see a same day view of the ?visitor flow? feature. Further, we would like to see a timely display of click costs where the display network is in use for a campaign. Finally, it would be very helpful if the documentation for Adwords was subjected to a thorough edit. The instructions and editorial content are still very opaque and certainly beyond the reach of non technical users. Nevertheless, we give very high marks to this promotional opportunity, and applaud Google on this effort.

If you are contemplating an Adwords campaign and would like to hear what we can do for you, then please contact us. Our monthly retained plans start at $3200.00.

IMB Enterprises, Inc. has the resources to successfully execute on this type of requirement. Please contact us to learn further. You can call Ira Michael Blonder at +1 631-673-2929 to further a discussion about our services plan. You may also email Ira at imblonder@imbenterprises.com.

? IMB Enterprises, Inc. & Ira Michael Blonder, 2012 All Rights Reserved

Source: http://www.imbenterprises.com/internet/adwords-has-become-an-accessible-and-valuable-tool-for-early-stage-enterprise-it-isvs-to-drive-sales-interest/

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Thursday, September 27, 2012

Optical mammography sheds new light on breast cancer -Breast ...

? Breast Cancer news ? Sep 26, 2012

New optical imaging technology developed at Tufts University School of Engineering could give doctors new ways to both identify breast cancer and monitor individual patients? response to initial treatment of the disease. A five-year clinical study of the procedure, funded by a $3.5 million grant from the National Institutes of Health, is now underway at Tufts Medical Center in Boston.

The non-invasive technology uses near infrared (NIR) light to scan breast tissue, and then applies an algorithm to interpret that information. Differences in light absorption allow identification of water, fats, and oxygen-rich and oxygen-poor tissue, the primary structures in breast tissue.

?The consensus is that x-ray mammography is very good at detecting lesions but it?s not as good at determining which suspicious lesions are really cancer,? says Professor of Biomedical Engineering Sergio Fantini, Ph.D., who is leading the research effort. The Tufts NIR technique could complement standard mammography, particularly for women younger than 40 who may have dense breast tissue that tends to obscure detail in x-rays.

Because it does not use ionizing radiation, the NIR technique can be applied multiple times over a short period without risk of radiation exposure, Fantini notes. Another advantage of the technology is that, unlike other breast imaging methods, it can obtain functional real-time images of metabolic changes, such as levels of hemoglobin concentration and oxygenation.?

"It?s been reported that patients who respond to breast cancer chemotherapy show a decrease in hemoglobin and water concentration and an increase in lipid concentration at the cancer site,? explains Fantini. ?This suggests that NIR imaging can be valuable not only in diagnosing breast cancer but in monitoring individual response to therapies without requiring repeated x-rays. For example, it could help determine if a patient is responding to neoadjuvant chemotherapy administered to shrink a tumor before surgery.?

Optical mammography is also more comfortable than traditional mammograms. The patient?s breasts are only lightly compressed between two horizontal glass panels and then illuminated by NIR light. A specialized software program displays real-time images of the breast as the optical system scans back and forth. A light detector within the system displays the intensity of the NIR beam as it is transmitted through the breast.

By using an algorithm based on the optical information, the technology generates breast images using the intensity of the transmitted light. The images are displayed automatically and can be read soon after the procedure, as is the case with x-ray mammograms. The technology can be packaged into compact, portable and handheld devices.

Clinical Testing

In collaboration with Roger Graham, M.D., director of Tufts Medical Center?s Breast Health Center, and Marc Homer, M.D., chief of mammography at Tufts Medical Center, Fantini and his team conducted ?proof of concept? tests to see if their procedure could corroborate information gathered with x-rays on two patients who each had suspicious lesions in one of their breasts.

The optical imaging was successful in enabling the team to identify cancerous tissue. ?The test results were compatible with what we found in the x-ray mammography,? Graham explains. ?It was also painless for the patients and eliminated radiation exposure.?

The team also includes Eric Miller, Ph.D., professor and chair of electrical and computer engineering and Misha Kilmer, Ph.D., professor of mathematics within the School of Arts and Sciences.

The NIH-funded study will investigate healthy women, women with breast cancer and women with benign breast lesions in an effort to examine the effectiveness of optical mammography in detecting breast cancer and distinguishing between malignant and benign tumors. The study will also look at breast cancer patients who are undergoing chemotherapy in order to characterize the power of optical mammography to determine patient response at the beginning of therapeutic treatment.
###

Fantini and his colleagues have published numerous papers on optical mammography: http://ase.tufts.edu/biomedical/research/fantini/publications/opticalMammography.asp.

This research is listed under award number 5R01CA154774-02

About Tufts University School of Engineering

Located on Tufts? Medford/Somerville campus, the School of Engineering offers a rigorous engineering education in a unique environment that blends the intellectual and technological resources of a world-class research university with the strengths of a top-ranked liberal arts college. Close partnerships with Tufts? excellent undergraduate, graduate and professional schools, coupled with a long tradition of collaboration, provide a strong platform for interdisciplinary education and scholarship. The School of Engineering?s mission is to educate engineers committed to the innovative and ethical application of science and technology in addressing the most pressing societal needs, to develop and nurture twenty-first century leadership qualities in its students, faculty, and alumni, and to create and disseminate transformational new knowledge and technologies that further the well-being and sustainability of society in such cross-cutting areas as human health, environmental sustainability, alternative energy, and the human-technology interface.

About Tufts Medical Center and Floating Hospital for Children Tufts Medical Center is an exceptional, not-for-profit, 415-bed academic medical center that is home to both a full-service hospital for adults and Floating Hospital for Children. Conveniently located in downtown Boston, the Medical Center is the principal teaching hospital for Tufts University School of Medicine. Floating Hospital for Children is the full-service children?s hospital of Tufts Medical Center and the principal pediatric teaching hospital of Tufts University School of Medicine. Tufts Medical Center is affiliated with seven community hospitals and with New England Quality Care Alliance, its community physicians? network.

###

Alex Reid
617-627-4173
Tufts University

Provided by ArmMed Media




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'Moon River' crooner Andy Williams dies at age 84

FILE - This Feb. 6, 2009 file photo shows Andy Williams arriving at the MusiCares Person of the Year tribute in Los Angeles. Williams, who had a string of gold albums and hosted several variety shows and specials such as, "The Andy Williams Show," died Tuesday, Sept. 25, 2012, at his home in Branson, Missouri, following a yearlong battle with bladder cancer, his Los Angeles-based publicist, Paul Shefrin, said Wednesday. He was 84. (AP Photo/Chris Pizzello, file)

FILE - This Feb. 6, 2009 file photo shows Andy Williams arriving at the MusiCares Person of the Year tribute in Los Angeles. Williams, who had a string of gold albums and hosted several variety shows and specials such as, "The Andy Williams Show," died Tuesday, Sept. 25, 2012, at his home in Branson, Missouri, following a yearlong battle with bladder cancer, his Los Angeles-based publicist, Paul Shefrin, said Wednesday. He was 84. (AP Photo/Chris Pizzello, file)

FILE - This Feb. 23, 1978 file photo shows performer and host Andy Williams at the Grammy Awards in Los Angeles. Williams, who had a string of gold albums and hosted several variety shows and specials like "The Andy Williams Show," died Tuesday, Sept. 25, 2012, at his home in Branson, Missouri, following a yearlong battle with bladder cancer, his Los Angeles-based publicist, Paul Shefrin, said Wednesday. He was 84. (AP Photo/Lennox McLendon, file)

FILE - In this July 25, 2004 file photo, U.S. singer Andy Williams smiles as he speaks to reporters during his news conference at a Tokyo hotel. Emmy-winning TV host and "Moon River" crooner Williams died Tuesday night, Sept, 25, 2012 at his home in Branson, Mo., following a year-long battle with bladder cancer. He was 84. (AP Photo/Shizuo Kambayashi, File)

FILE - In a May 12, 1961 file photo, Andy Williams performs a song on a television show. Emmy-winning TV host and "Moon River" crooner Williams died Tuesday night, Sept, 25, 2012 at his home in Branson, Mo., following a year-long battle with bladder cancer. He was 84. (AP Photo, File)

FILE - This Aug. 30, 1974 file photo shows entertainer Andy Williams in New York. Williams, who had a string of gold albums and hosted several variety shows and specials such as, "The Andy Williams Show," died Tuesday, Sept. 25, 2012, at his home in Branson, Missouri, following a yearlong battle with bladder cancer, his Los Angeles-based publicist, Paul Shefrin, said Wednesday. He was 84. (AP Photo/Jerry Mosey, file)

(AP) ? With a string of gold albums, a hit TV series and the signature "Moon River," Andy Williams was a voice of the 1960s, although not the '60s we usually hear about.

"The old cliche says that if you can remember the 1960s, you weren't there," the singer once recalled. "Well, I was there all right, but my memory of them is blurred ? not by any drugs I took but by the relentless pace of the schedule I set myself."

Williams' plaintive tenor, boyish features and easy demeanor helped him outlast many of the rock stars who had displaced him and such fellow crooners as Frank Sinatra and Perry Como. He remained on the charts into the 1970s, and continued to perform in his 80s at the Moon River Theatre he built in Branson, Mo.

In November 2011, when Williams announced that he had been diagnosed with bladder cancer, he vowed to return to performing the following year: His 75th in show business.

Williams died Tuesday night at his home in Branson following a yearlong battle with the disease, his Los Angeles-based publicist, Paul Shefrin, said Wednesday. He was 84.

He became a major star the same year as Elvis Presley, 1956, with the Sinatra-like swing "Canadian Sunset," and for a time he was pushed into such Presley imitations as "Lips of Wine" and the No. 1 smash "Butterfly."

But he mostly stuck to what he called his "natural style," and kept it up throughout his career. In 1970, when even Sinatra had given up and (temporarily) retired, Williams was in the top 10 with the theme from "Love Story," the Oscar-winning tearjerker. He had 18 gold records and three platinum, was nominated for five Grammy awards and hosted the Grammy ceremonies for several years.

Movie songs became a specialty, from "Love Story" and "Days of Wine and Roses" to "Moon River." The longing Johnny Mercer-Henry Mancini ballad was his most famous song, even though he never released it as a single because his record company feared such lines as "my huckleberry friend" were too confusing and old-fashioned for teens.

The song was first performed by Audrey Hepburn in the beloved 1961 film "Breakfast at Tiffany's," but Mancini thought "Moon River" ideal for Williams, who recorded it in "pretty much one take" and also sang it at the 1962 Academy Awards. Although "Moon River" was covered by countless artists and became a hit single for Jerry Butler, Williams made the song his personal brand. In fact, he insisted on it.

"When I hear anybody else sing it, it's all I can to do stop myself from shouting at the television screen, 'No! That's my song!'" Williams wrote in his 2009 memoir, titled, fittingly, "Moon River and Me."

"The Andy Williams Show," which lasted in various formats through the 1960s and into 1971, won three Emmys and featured Williams alternately performing his stable of hits and bantering casually with his guest stars.

It was on that show that Williams ? who launched his own career as part of an all-brother quartet ? introduced the world to another clean-cut act ? the original four singing Osmond Brothers of Utah. Their younger sibling Donny also made his debut on Williams' show, in 1963 when he was 6 years old. Four decades later, the Osmonds and Williams would find themselves in close proximity again, sharing Williams' theater in Branson.

Williams did book some rock and soul acts, including the Beach Boys, the Temptations and Smokey Robinson. On one show, in 1970, Williams sang "Heaven Help Us All" with Ray Charles, Mama Cass and a then-little known Elton John, a vision to Williams in his rhinestone glasses and black cape. But Williams liked him and his breakthrough hit "Your Song" enough to record it himself.

Williams' act was, apparently, not an act. The singer's unflappable manner on television and in concert was mirrored offstage.

"I guess I've never really been aggressive, although almost everybody else in show business fights and gouges and knees to get where they want to be," he once said. "My trouble is, I'm not constructed temperamentally along those lines

His wholesome image endured one jarring interlude. In 1976, his ex-wife, former Las Vegas showgirl Claudine Longet, shot and killed her lover, skiing champion Spider Sabich. The Rolling Stones mocked the tragedy in "Claudine," a song so pitiless that it wasn't released until decades later. Longet, who said it was an accident, spent only a week in jail. Williams stood by her. He escorted her to the courthouse, testified on her behalf and provided support for her and their children, Noelle, Christian and Robert.

Also in the 1970s, Williams was seen frequently in the company of Ethel Kennedy, Robert Kennedy's widow. The singer denied any romantic involvement.

He was born Howard Andrew Williams in Wall Lake, Iowa, on Dec. 3, 1927. In his memoir, Williams remembered himself as a shy boy who concealed his insecurity "behind a veneer of cheek and self-confidence." Of Wall Lake, Williams joked that it was so small, and had so little to do, that crowds would gather just to watch someone get a haircut.

Williams began performing with his older brothers Dick, Bob and Don in the local Presbyterian church choir. Their father, postal worker and insurance man Jay Emerson Williams, was the choirmaster and the force behind his children's career.

When Andy was 8, Williams' father brought the kids for an audition on Des Moines radio station WHO's Iowa Barn Dance. They were initially turned down, but Jay Emerson Williams and the young quartet kept returning and they were finally accepted, their show bringing them attention from Chicago, Cincinnati and Hollywood. Another star at WHO was a young sportscaster named Ronald Reagan, who would later praise Williams as a "national treasure."

The brothers joined Bing Crosby in recording the hit "Swinging on a Star" in 1944 for Crosby's film "Going My Way," and Andy, barely a teenager, was picked to dub Lauren Bacall's voice on a song for the film "To Have and Have Not." His voice stayed in the film until the preview, when it was cut because it didn't sound like Bacall's.

Later the brothers worked with Kay Thompson of eventual "Eloise" fame, then a singer who had taken a position as vocal coach at MGM studios, working with Judy Garland, June Allyson and others. After three months of training, Thompson and the Williams Brothers broke in their show at the El Rancho Room in Las Vegas to a huge ovation. They drew rave reviews in New York, Los Angeles and across the nation, earning a peak of $25,000 a week.

Williams, analyzing their success, once said: "Somehow we managed to work up and sustain an almost unbearable pitch of speed and rhythm."

After five years, the three older brothers, who were starting their own families, had tired of the constant travel and left to pursue other careers.

Williams initially struggled as a solo act and was so broke at one point that he resorted to eating food intended for his two dogs.

"I had no money for food, so I ate it," he recalled in 2001, "and it actually was damned good."

A two-year TV stint on Steve Allen's "Tonight Show" and a contract with Cadence Records turned things around. Williams later formed his own label, Barnaby Records, which released music by the Everly Brothers, Ray Stevens and Jimmy Buffett.

Williams was a lifelong Republican who once accused President Obama of "following Marxist theory." But he acknowledged experimenting with LSD, opposed the Nixon administration's efforts in the 1970s to deport John Lennon, and, in 1968, was an energetic supporter of Robert Kennedy's presidential campaign. When Kennedy was assassinated in Los Angeles in June 1968, just after winning the California Democratic primary, Williams sang "The Battle Hymn of the Republic" at his funeral.

"We chose that song because he used it on the campaign trail," Williams later said of Kennedy, who had been a close friend. "He had a terrible voice but he loved to sing that song. The only way I got through singing in church that day was by saying, 'This is my job. I can't let emotion get in the way of the song.' I really concentrated on not thinking about him."

After leaving TV, Williams headed back on the road, where his many Christmas shows and albums made him a huge draw during the holidays. One year in Des Moines, however, a snowstorm kept the customers away, and the band's equipment failed to reach Chicago in time for the next night's show, forcing the musicians to borrow instruments from a high school band.

"No more tours," Williams decreed.

He decided to settle in Branson, the self-proclaimed "live entertainment capital of the country," with its dozens of theaters featuring live music, comedy and magic acts.

When he arrived in 1992, the town was dominated by country music performers, but Williams changed that, building the classy, $13 million Andy Williams Moon River Theater in the heart of the city's entertainment district and performing two shows a night, six days a week, nine months of the year. Only in recent years did he begin to cut back to one show a night.

Not surprisingly, his most popular time of the year was Christmas, although he acknowledged that not everyone in Hollywood accepted his move to the Midwest.

"The fact is most of my friends in L.A. still think I'm nuts for coming here," he told The Associated Press in 1998.

He and his second wife, the former Debbie Haas, divided their time between homes in Branson and Palm Springs, where he spent his leisure hours on the golf course when Branson's theaters were dark during the winter months following Christmas.

Retirement was not on his schedule. As he told the AP in 2001: "I'll keep going until I get to the point where I can't get out on stage."

Williams is survived by his wife, Debbie, and his three children, Robert, Noelle and Christian.

___

Thomas reported from Los Angeles. AP Entertainment Writer Nekesa Mumbi Moody contributed to this report from Nashville, Tenn.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-09-26-Obit-Andy%20Williams/id-f5261640175045798f5f772ccf4846f8

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An old drug finds a new use

An old drug finds a new use [ Back to EurekAlert! ] Public release date: 27-Sep-2012
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Contact: Michele Sequeira
MSequeira@salud.unm.edu
505-925-0486
University of New Mexico Cancer Center

UNM Cancer Center researchers win prestigious NCI Provocative Questions grant to investigate how NSAIDs protect against cancer

Most drugs take ten yearsand frequently, moreto go from concept to FDA approval. One way to reduce this time investment is to look for already-approved drugs that could be put to new uses. And that's just what Angela Wandinger-Ness, PhD, UNM Professor of Pathology, and Laurie Hudson, PhD, UNM Professor of Pharmaceutical Sciences, have done. Drs. Wandinger-Ness and Hudson, both at the University of New Mexico Cancer Center, were recently awarded a two-year exploratory National Cancer Institute (NCI) grant to investigate the use of R-ketorolac against ovarian cancer cells.

Ketorolac is an NSAID, or non-steroidal anti-inflammatory drug. The FDA approved its use for pain relief in humans in 1991. "Inflammation is an important process in cancer," says Dr. Hudson. Dr. Wandinger-Ness adds, "So the provocative question is: why? Why are some NSAIDs protective in cancer, while others are not? What are the protective mechanisms, anti-inflammatory or other basis? We know that NSAIDs work, but lack a complete understanding of the basis of anti-cancer efficacy."

In fact, several areas in cancer research are not well understood. So to consider some of these areas now that new technologies can be used to explore them, the NCI created a list of 24 Provocative Questions and awarded grants in these areas. Dr. Wandinger-Ness and Dr. Hudson are two of only 57 Provocative Questions grant recipients. Their work centers on demonstrating one path by which anti-inflammatory drugs can protect against cancer.

Dr. Wandinger-Ness's work with GTPasesthe chemical switches inside a cell which regulate processes ranging from cell growth to how cells adhere to each otherdovetailed nicely with Dr. Hudson's work on how ovarian cancer spreads. They have been collaborating now for over 5 years. Their collaboration also synergizes with the work of other researchers"Team Science," as Dr. Wandinger-Ness calls it.

Capitalizing on the flow cytometry expertise of Larry Sklar, PhD, UNM Professor of Pathology, and the drug conformation computer modeling expertise of Tudor Oprea, MD, PhD, UNM Professor of Biochemistry and Molecular Biology (both at UNM Cancer Center), Dr. Wandinger-Ness and Dr. Hudson identified drugs they thought would control GTPases in a cell. The process was similar to finding the proverbial needle in the haystack. "Technologies like flow cytometry and advanced computer modeling allow this kind of discovery to be made," says Dr. Hudson.

The first drug the team found, R-naproxen, was FDA approved but not available for human use so they found a second candidate, R-ketorolac. Now, working with Jennifer Golden, PhD, Assistant Director at the Kansas University Specialized Chemistry Center, they are precisely targeting particular types of GTPases in a cell to modulate cancer cell behaviors that affect tumor growth and spread. Their many experiments and initial animal studies using R-ketorolac against ovarian cancer look very promising in keeping tumor growth in check.

R-naproxen and R-ketorolac are not anti-inflammatory agents, though. While their mirror images, S-naproxen and S-ketorolac, target a specific class of proteins called cyclooxygenases that strongly inhibit inflammationmaking them potent NSAIDsR-naproxen and R-ketorolac do not have these properties. It's a provocative twist to Provocative Question number 5 on the NCI's list.

Ketorolac is marketed as Toradol for post-operative pain and consists of an R-ketorolac and S-ketorolac mixture allowing both forms of the drug to be administered in a single dose. Although both forms have exactly the same chemical formula, they are not the same molecule in three dimensions just as your left hand and your right hand are not the same. Thus, they behave differently inside a cell because the drugs interact with different proteins just as "the right hand only fits a right hand glove, but doesn't fit into the left hand glove," as Dr. Hudson explains.

Dr. Wandinger-Ness and Dr. Hudson are now proposing that R-ketorolac has a possible new activity inside the cell. "We think R-ketorolac interacts with the GTPases," says Dr. Wandinger-Ness. GTPases control cell growth and cell adherence, two important characteristics of ovarian cancer cells. "We have good of evidence that R-naproxen interacts with this GTPase pathway," Dr. Hudson says. So now, through their NCI grant, they're working to demonstrate that R-ketorolac can inhibit the specific GTPase cascades that enable ovarian cancer cell behaviors contributing to tumor growth and spread.

Dr. Wandinger-Ness and Dr. Hudson along with Carolyn Muller, MD, UNM Professor of Obstetrics and Gynecologic Oncology, want to expand these studies to benefit people. That's why, through several other grants, they intend to begin Phase I clinical trials of R-ketorolac for ovarian cancer. "Building something like this requires a long time and it requires seed money," says Dr. Wandinger-Ness. "We want to acknowledge cancer donors and the UNM Cancer Center grant." Through this complex network of scientific teamwork and funding, they'll be able to bring this research to the clinic far faster than any new drug to the marketplace.

###

About the National Cancer Institute Grant

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R21CA170375. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the National Cancer Institute's Provocative Questions Project

The Provocative Questions project emerged from discussion among a number of veteran cancer researchers that noticed there were many questions some important but not very obvious, some that had been asked but abandoned in the past because we didn't have ways to study or address them, some sparked by new discoveries or novel technologies that could stimulate the NCI's research communities to use laboratory, clinical, and population sciences in especially effective and imaginative ways. Over the course of 18 months, NCI solicited questions from scientists in various fields and at different stages in their careers, ultimately settling on 24 questions that, if answered, could lead to significant research advances. In a departure from its traditional grant-making process, NCI released a special solicitation just for research related to these 24 questions and empaneled a custom set of peer review groups to score the more than 700 applications NCI received. More than 50 grants, attempting to answer 20 of the 24 proposed questions, are being funded this year from that set of applications. These grants are not intended to represent the NCI's full range of priorities in cancer research, but rather represent a new and different way to identify and address research needs in cancer by challenging researchers to delve into key areas that require more in depth study.

About the UNM Cancer Center

The UNM Cancer Center is the Official Cancer Center of New Mexico and the only National Cancer Institute (NCI)-designated cancer center in the state. One of just 67 NCI-designated cancer centers nationwide, the UNM Cancer Center is recognized for its scientific excellence, contributions to cancer research and delivery of medical advances to patients and their families. It is home to New Mexico's largest team of board-certified oncology physicians and research scientists, representing every cancer specialty and hailing from prestigious institutions such as MD Anderson, Johns Hopkins and the Mayo Clinic. The UNM Cancer Center treats more than 65 percent of the adults and virtually all of the children in New Mexico affected by cancer, from every county in the state. In 2010, it provided care to more than 15,800 cancer patients. The Center's research programs are supported by nearly $60 million annually in federal and private funding. Learn more at http://cancer.unm.edu.

UNM Cancer Center contact information

Dorothy Hornbeck, JKPR, (505) 340-5929, dhornbeck@jameskorenchen.com

Michele Sequeira, UNM Cancer Center, (505) 925-0486, msequeira@salud.unm.edu


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An old drug finds a new use [ Back to EurekAlert! ] Public release date: 27-Sep-2012
[ | E-mail | Share Share ]

Contact: Michele Sequeira
MSequeira@salud.unm.edu
505-925-0486
University of New Mexico Cancer Center

UNM Cancer Center researchers win prestigious NCI Provocative Questions grant to investigate how NSAIDs protect against cancer

Most drugs take ten yearsand frequently, moreto go from concept to FDA approval. One way to reduce this time investment is to look for already-approved drugs that could be put to new uses. And that's just what Angela Wandinger-Ness, PhD, UNM Professor of Pathology, and Laurie Hudson, PhD, UNM Professor of Pharmaceutical Sciences, have done. Drs. Wandinger-Ness and Hudson, both at the University of New Mexico Cancer Center, were recently awarded a two-year exploratory National Cancer Institute (NCI) grant to investigate the use of R-ketorolac against ovarian cancer cells.

Ketorolac is an NSAID, or non-steroidal anti-inflammatory drug. The FDA approved its use for pain relief in humans in 1991. "Inflammation is an important process in cancer," says Dr. Hudson. Dr. Wandinger-Ness adds, "So the provocative question is: why? Why are some NSAIDs protective in cancer, while others are not? What are the protective mechanisms, anti-inflammatory or other basis? We know that NSAIDs work, but lack a complete understanding of the basis of anti-cancer efficacy."

In fact, several areas in cancer research are not well understood. So to consider some of these areas now that new technologies can be used to explore them, the NCI created a list of 24 Provocative Questions and awarded grants in these areas. Dr. Wandinger-Ness and Dr. Hudson are two of only 57 Provocative Questions grant recipients. Their work centers on demonstrating one path by which anti-inflammatory drugs can protect against cancer.

Dr. Wandinger-Ness's work with GTPasesthe chemical switches inside a cell which regulate processes ranging from cell growth to how cells adhere to each otherdovetailed nicely with Dr. Hudson's work on how ovarian cancer spreads. They have been collaborating now for over 5 years. Their collaboration also synergizes with the work of other researchers"Team Science," as Dr. Wandinger-Ness calls it.

Capitalizing on the flow cytometry expertise of Larry Sklar, PhD, UNM Professor of Pathology, and the drug conformation computer modeling expertise of Tudor Oprea, MD, PhD, UNM Professor of Biochemistry and Molecular Biology (both at UNM Cancer Center), Dr. Wandinger-Ness and Dr. Hudson identified drugs they thought would control GTPases in a cell. The process was similar to finding the proverbial needle in the haystack. "Technologies like flow cytometry and advanced computer modeling allow this kind of discovery to be made," says Dr. Hudson.

The first drug the team found, R-naproxen, was FDA approved but not available for human use so they found a second candidate, R-ketorolac. Now, working with Jennifer Golden, PhD, Assistant Director at the Kansas University Specialized Chemistry Center, they are precisely targeting particular types of GTPases in a cell to modulate cancer cell behaviors that affect tumor growth and spread. Their many experiments and initial animal studies using R-ketorolac against ovarian cancer look very promising in keeping tumor growth in check.

R-naproxen and R-ketorolac are not anti-inflammatory agents, though. While their mirror images, S-naproxen and S-ketorolac, target a specific class of proteins called cyclooxygenases that strongly inhibit inflammationmaking them potent NSAIDsR-naproxen and R-ketorolac do not have these properties. It's a provocative twist to Provocative Question number 5 on the NCI's list.

Ketorolac is marketed as Toradol for post-operative pain and consists of an R-ketorolac and S-ketorolac mixture allowing both forms of the drug to be administered in a single dose. Although both forms have exactly the same chemical formula, they are not the same molecule in three dimensions just as your left hand and your right hand are not the same. Thus, they behave differently inside a cell because the drugs interact with different proteins just as "the right hand only fits a right hand glove, but doesn't fit into the left hand glove," as Dr. Hudson explains.

Dr. Wandinger-Ness and Dr. Hudson are now proposing that R-ketorolac has a possible new activity inside the cell. "We think R-ketorolac interacts with the GTPases," says Dr. Wandinger-Ness. GTPases control cell growth and cell adherence, two important characteristics of ovarian cancer cells. "We have good of evidence that R-naproxen interacts with this GTPase pathway," Dr. Hudson says. So now, through their NCI grant, they're working to demonstrate that R-ketorolac can inhibit the specific GTPase cascades that enable ovarian cancer cell behaviors contributing to tumor growth and spread.

Dr. Wandinger-Ness and Dr. Hudson along with Carolyn Muller, MD, UNM Professor of Obstetrics and Gynecologic Oncology, want to expand these studies to benefit people. That's why, through several other grants, they intend to begin Phase I clinical trials of R-ketorolac for ovarian cancer. "Building something like this requires a long time and it requires seed money," says Dr. Wandinger-Ness. "We want to acknowledge cancer donors and the UNM Cancer Center grant." Through this complex network of scientific teamwork and funding, they'll be able to bring this research to the clinic far faster than any new drug to the marketplace.

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About the National Cancer Institute Grant

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R21CA170375. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the National Cancer Institute's Provocative Questions Project

The Provocative Questions project emerged from discussion among a number of veteran cancer researchers that noticed there were many questions some important but not very obvious, some that had been asked but abandoned in the past because we didn't have ways to study or address them, some sparked by new discoveries or novel technologies that could stimulate the NCI's research communities to use laboratory, clinical, and population sciences in especially effective and imaginative ways. Over the course of 18 months, NCI solicited questions from scientists in various fields and at different stages in their careers, ultimately settling on 24 questions that, if answered, could lead to significant research advances. In a departure from its traditional grant-making process, NCI released a special solicitation just for research related to these 24 questions and empaneled a custom set of peer review groups to score the more than 700 applications NCI received. More than 50 grants, attempting to answer 20 of the 24 proposed questions, are being funded this year from that set of applications. These grants are not intended to represent the NCI's full range of priorities in cancer research, but rather represent a new and different way to identify and address research needs in cancer by challenging researchers to delve into key areas that require more in depth study.

About the UNM Cancer Center

The UNM Cancer Center is the Official Cancer Center of New Mexico and the only National Cancer Institute (NCI)-designated cancer center in the state. One of just 67 NCI-designated cancer centers nationwide, the UNM Cancer Center is recognized for its scientific excellence, contributions to cancer research and delivery of medical advances to patients and their families. It is home to New Mexico's largest team of board-certified oncology physicians and research scientists, representing every cancer specialty and hailing from prestigious institutions such as MD Anderson, Johns Hopkins and the Mayo Clinic. The UNM Cancer Center treats more than 65 percent of the adults and virtually all of the children in New Mexico affected by cancer, from every county in the state. In 2010, it provided care to more than 15,800 cancer patients. The Center's research programs are supported by nearly $60 million annually in federal and private funding. Learn more at http://cancer.unm.edu.

UNM Cancer Center contact information

Dorothy Hornbeck, JKPR, (505) 340-5929, dhornbeck@jameskorenchen.com

Michele Sequeira, UNM Cancer Center, (505) 925-0486, msequeira@salud.unm.edu


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Source: http://www.eurekalert.org/pub_releases/2012-09/uonm-aod092712.php

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